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Faculty of Mathematics and Natural SciencesInstitute for Zoology

Publications

Overview per year

 

2023

  • Hatzold J, Nett V, Brantsch S, Zhang JL, Armistead J, Wessendorf H, Stephens R, Humbert PO, Iden S and Hammerschmidt, M. (2023). Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects. PLOS Genetics 19(8): e1010873. https://doi.org/10.1371/journal.pgen.101087

  • Pogoda, HM., Riedl-Quinkertz, I., Hammerschmidt, M. (2023). Direct BMP signaling to chordoblasts is required for the initiation of segmented notochord sheath mineralization in zebrafish vertebral column development. Front Endocrinol (Lausanne). 14:1107339. doi: 10.3389/fendo.2023.1107339

2022

  • Bagivalu Lakshminarasimha A, Puvvada M, Hammerschmidt M, Michel M (2022). Leptin modulates oocyte maturation by a central and a direct pathway in zebrafish. J. Endocrinol. 254, 1-12

  • Leibold S, Bagivalu Lakshminarasimha A, Gremse F, Hammerschmidt M, Michel M. Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish (2022). PLoS One 17, e0267933

  • Chen L, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Galati A, Palumbo V, Kobin MA, Tartaglia GG, Colantoni A, Proietti G, Wu Y, Hammerschmidt M, De Pittà C, Sales G, Salzman J, Pellizzoni L, Wirth B, Schiavi ED, Gatti M, Artandi SE, Raffa GD (2022). TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration. Nucleic Acids Res. gkac659

  • Zhang, J.L., Richetti, S., Ramezani, T., Welcker, D., Lütke, S., Pogoda, H.M., Hatzold, J., Zaucke, F., Keene. D.R., Bloch, W., Sengle, G. and Hammerschmidt, M. (2022). Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2. Matrix Biol. 122, 132-15

 

2021

  • Stielow, B., Zhou, Y., Cao, Y., Simon, C., Pogoda, H.M., Jiang, J., Ren, Y., Phanor, S.K., Rohner, I., Nist, A., Stiewe, T., Hammerschmidt, M., Shi, Y., Bulyk, M.L., Wang, Z. and Liefke, R. (2021). The SAM-domain-containing protein 1 (SAMD1) functions as a novel chromatin regulator at unmethylated CpG islands. Sci. Adv. 7, eabf2229

  • Hatzold, J., Wessendorf, H., Pogoda, H.M., Bloch, W. and Hammerschmidt, M. (2021). The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development. Dev. Biol. 476, 148-170

  • Welcker, D., Stein, C., Feitosa, N.M., Armistead, J., Zhang, J.L., Lütke, S., Kleinridders, A., Brüning, J.C., Eming, S.A., Sengle, G., Niehoff, A., Bloch, W. and Hammerschmidt, M. (2021). Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions. Sci. Rep. 11, 17926

  • Martínez-Morcillo, F.J., Cantón-Sandoval, J., Martínez-Navarro, F.J., Isabel Cabas, I., Martínez-Vicente, I., Armistead, A., Hatzold, J., López-Muñoz, A., Martínez-Menchón, T., Corbalán-Vélez, R., Lacal, J., Hammerschmidt,  M., García-Borrón, J.C., García-Ayala, A., Cayuela, M.L., Pérez-Oliva, A.B., García-Moreno, D. and Mulero, V. (2021). NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death. PLoS Biol. 19, e3001455

 

2020

  • Armistead, J., Hatzold, J., van Roye, A., Fahle E. and Hammerschmidt, M. (2020). Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase. J. Cell Biol. 219, e201905190

  • Ichino, N., Serres, M.R., Urban, R.M., Urban, M.D., Treichel, A.J., Schaefbauer, K.J., Greif, L.E., Varshney, G.K., Skuster, K.J., McNulty, M.S., Daby, C.L., Wang, Y., Liao, H.K., El-Rass, S., Ding, Y., Liu, W., Anderson, J.L., Wishman, M.D., Sabharwal, A., Schimmenti, L.A., Sivasubbu, S., Balciunas, D., Hammerschmidt, M., Farber, S.A., Wen, X.Y., Xu, X., McGrail, M., Essner, J.J., Burgess, S.M., Clark, K.J., Ekker, S.C. (2020). Building the vertebrate codex using the gene breaking protein trap library. Elife 9, e54572

  • Reinoss, P., Ciglieri, E., Minere, M., Bremser, S., Klein, A., Löhr, H., Fuller, P.M., Büschges, A., Kloppenburg, P., Fenselau, H., and Hammerschmidt, M. (2020). Hypothalamic Pomc neurons innervate the spinal cord and modulate the excitability of premotor circuits. Curr. Biol. 30, 4579-4593

 

2019

  • Jurkute, N., Leu, C., Pogoda, H.M., Arno, G., Robson, A.G., Nürnberg, G., Altmüller, J., Thiele, H., Motameny, S., Toliat, M.R., Powell, K., Höhne, W., Michaelides, M., Webster, A.R., Moore, A.T., Hammerschmidt, M., Nürnberg, P., Yu-Wai-Man, P. and Votruba, M. (2019). SSBP1 mutations in dominant optic atrophy with variable retinal degeneration. Ann Neurol. 86, 368-383

  • Di Bella, D.J., Carcagno, A.L., Bartolomeu, M.L., Pardi, M.B., Löhr,H., Siegel, N., Hammerschmidt, M., Marín-Burgin, A. and Lanuza, G.M. (2019). Ascl1 balances neuronal versus ependymal fate in the spinal cord central canal. Cell Rep. 28, 2264-2274

 

2018

  • van der Ven, A.T., Kobbe, B., Kohl, S., Shril, S., Pogoda, H.M., Imhof, T., Ityel, H., Vivante, A., Chen, J., Hwang, D.Y., Connaughton, D.M., Mann, N., Widmeier, E., Taglienti, M., Schmidt, J.M., Nakayama, M., Senguttuvan, P., Kumar, S., Tasic, V., Kehinde, E.O., Mane, S.M., Lifton. R.P., Soliman, N., Lu, W., Bauer, S.B., Hammerschmidt, M., Wagener, R, and Hildebrandt, F.A. (2018). Homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux. PLoS One 13, e0191224

  • Mendoza-Ferreira, N., Coutelier, M., Janzen, E., Hosseinibarkooie, S., Löhr, H., Schneider, S., Milbradt, J., Karakaya, M., Riessland, M., Pichlo, C., Torres-Benito, L., Singleton, A., Zuchner, S., Brice, A., Durr, A., Hammerschmidt, M., Stevanin, G. and Wirth, B. (2018). Biallelic CHP1 mutation causes human autosomal recessive ataxia by impairing NHE1 function. Neurol Genet. 4, e209

  • Pogoda, H.M., Riedl-Quinkertz, I., Löhr, H., Waxman, J.S., Dale, R.M., Topczewski, J., Schulte-Merker, S. and Hammerschmidt, M. (2018). Direct activation of chordoblasts by retinoic acid is required for segmented centra formation during zebrafish spine development. Development 145, dev.159418

  • Löhr, H., Hess, S., Pereira, M.M.A., Reinoß, P., Leibold, L., Schenkel, C., Wunderlich, C.M., Kloppenburg, P., Brüning, J.C. and Hammerschmidt, M. (2018). Diet-induced growth is regulated via acquired leptin resistance and engages a Pomc-Somatostatin-Growth hormone circuitry. Cell Rep. 23, 1728-1741

  • McMillan, S.C., Zhang, J., Phan, H.E., Jeradi, S., Probst, L., Hammerschmidt, M. and Akimenko, M.A. (2018). A regulatory pathway involving retinoic acid and calcineurin demarcates and maintains joint cells and osteoblasts in the fin regenerate. Development 145, dev.161158

  • Janzen, E., Mendoza-Ferreira, N., Hosseinibarkooie, S., Schneider, S., Hupperich, K., Tschanz, T., Grysko, V., Riessland, M., Hammerschmidt, M., Rigo, F., Bennett, C.F., Kye, M.J., Torres-Benito, L. and Wirth, B. (2018). CHP1 reduction ameliorates spinal muscular atrophy pathology by restoring calcineurin activity and endocytosis. Brain 141, 2343-2361

  • Richardson, R. and Hammerschmidt M. (2018). The role of Rho kinase (Rock) in re-epthelialization of adult zebrafish skin wounds. Small GTPases 9, 230-236

 

2017

  • Riessland, M., Kaczmarek, A., Schneider, S., Swoboda, K.J., Löhr, H., Bradler, C., Grysko, V., Dimitriadi, M., Hosseinibarkooie, S., Torres-Benito, L., Peters, M., Upadhyay, A., Biglari, N., Kröber, S., Hölker, I., Garbes, L., Gilissen, C., Hoischen, A., Nürnberg, G., Nürnberg, P., Walter, M., Rigo, F., Bennett, C.F., Kye, M.J., Hart, A.C., Hammerschmidt, M., Kloppenburg, P., Wirth, B. (2017). Neurocalcin D suppression protects against spinal muscular atrophy in humans and across species by restoring impaired endocytosis. Am. J. Hum. Genet. 100, 297-315

  • Lessel, D., Wu, D., Trujillo, C., Ramezani, T., Lessel, I., Alwasiyah, M.K., Saha, B., Hisama, F.M., Rading, K., Goebel, I., Schütz, P., Speit, G., Högel, J., Thiele, H., Nürnberg, G., Nürnberg, P., Hammerschmidt, M., Zhu, Y., Tong, D.R., Katz, C., Martin, G.M., Oshima, J., Prives, C. and Kubisch, C. (2017). Dysfunction of the MDM2/p53 axis is linked to premature aging. J Clin Invest.127, 3598-3608

 

2016

  • Jeradi, S. and Hammerschmidt, M. (2016). Retinoic acid-induced premature osteoblast-to-preosteocyte transitioning has multiple effects on calvarial development. Development 143, 1205-1216

  • Richardson, R., Metzger, M., Knyphausen, P., Ramezani, T., Kraus, C. Schmelzer, E., Hammerschmidt, M. (2016). Re-epithelialisation of cutaneous wounds in adult zebrafish combines mechanisms of wound closure in embryonic and adult mammals. Development 143, 2077-2088

  • Hatzold, J., Beleggia, F., Herzig, H., Altmüller, J., Nürnberg, P., Bloch, W., Wollnik, B., Hammerschmidt, M. (2016). Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit. eLife 5, e14277

  • Hosseinibarkooie, S., Peters, M., Torres-Benito, L., Rastetter, R.H., Hupperich, K., Hoffmann, A., Mendoza-Ferreira, N., Kaczmarek, A., Janzen, E., Milbradt, J., Lamkemeyer, T., Rigo, F., Bennett, C.F., Guschlbauer, C., Büschges, A., Hammerschmidt, M., Riessland, M., Kye, M.J., Clemen, C.S., Wirth, B. (2016). The power of human protective modifiers: PLS3 and CORO1C unravel impaired endocytosis in spinal muscular atrophy and rescue SMA phenotype. Am. J. Hum. Genet. 99, 647-665

 

2015

  • Schwamb, B., Pick, R., Fernández, S.B., Völp, K., Heering, J., Dötsch, V., Bösser, S., Jung, J., Beinoraviciute-Kellner, R., Wesely, J., Zörnig, I., Hammerschmidt, M., Nowak, M., Penzel, R., Zatloukal, K., Joos, S., Rieker, R.J., Agaimy, A., Söder, S., Reid-Lombardo, K., Kendrick, M.L., Bardsley, M.R., Hayashi, Y., Asuzu, D.T., Syed, S.A., Ordog, T. and Zörnig, M. (2015). FAM96A is a novel pro-apoptoic tumor suppressor in gastrointestinal stromal tumors. Int. J. Cancer 137, 1318-1329

  • Leibold, S. and Hammerschmidt, M. (2015). Long-term hyperphagia and caloric restriction caused by low- or high-density husbandry have differential effects on zebrafish postembryonic development, somatic growth, fat accumulation and reproduction. PLoS One 10, e0120776

  • Westcot, S.E., Hatzold, J., Urban, M.D., Richetti, S.K., Skuster, K.J., Harm, R.M., Lopez Cervera, R., Umemoto N., McNulty, M.S., Clark, K.J., Hammerschmidt, M., Ekker, S,C. (2015). Protein-Trap insertional mutagenesis uncovers new genes involved in zebrafish skin development, including a neuregulin 2a-based ErbB signaling pathway required during median fin fold morphogenesis. PLoS One 10, e0130688

  • Knipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA (2015). Interleukin-4 receptor alpha signaling in myeloid cells controls collagen fibril assembly in skin repair. Immunity 43, 803-816

 

2014

  • Keupp, K., Li, Y., Vargel, I., Hoischen, A., Richardson, R., Neveling, K., Alanay, Y., Uz, E., Elcioğlu, N., Rachwalski, M., Kamaci, S., Tunçbilek, G., Akin, B., Grötzinger, J., Konas, E., Mavili, E., Müller-Newen, G., Collmann, H., Roscioli, T., Buckley, M.F., Yigit, G., Gilissen, C., Kress, W., Veltman, J., Hammerschmidt, M., Akarsu, N.A. and Wollnik, B. (2014). Mutations in the interleukin receptor IL11RA cause autosomal Crouzon-like craniosynostosis. Mol. Genet. Genomic Med. 1, 223-237

  • Fischer, B., Metzger, M., Richardson, R., Knyphausen, P., Ramezani, T., Franzen, R., Schmelzer, E., Bloch, W., Carney, T.J. and Hammerschmidt, M. (2014). p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish. PLoS Genet. 10, e1004048

  • Richardson, R., Gebauer, J.M., Zhang, J.L., Kobbe, B., Keene, D.R., Karlson, K.R., Richetti, S., Wohl, A.P., Sengle, G., Neiss, W.F., Paulsson, M., Hammerschmidt, M.* and Wagener, R.* (2014). AMACO is a novel component of the basement membrane associated Fraser complex. J. Invest. Dermatol. 134, 1313-1322 (*joint corresponding authors)

  • Wishart, T.M., Mutsaers, C.A., Riessland, M., Reimer, M.M., Hunter, G., Hannam, M.L,, Eaton, S.L., Fuller, H.R., Roche, S.L., Somers, E., Morse, R., Young, P.J., Lamont, D.J., Hammerschmidt, M., Joshi, A., Hohenstein, P., Morris, G.E., Parson, S.H., Skehel, P.A., Becker, T., Robinson, I.M., Becker, C.G., Wirth, B. and Gillingwater, T.H. (2014). Dysregulation of ubiquitin homeostasis and beta-catenin signaling promote muscular atrophy. J. Clin. Invest. 124, 1821-1834

  • Chowdhury, A., Herzog, C., Hasselblatt L, Khouzani, H. L., Zhang, J., Hammerschmidt M, Rudat, C., Kispert, A., Gaestel, M., Menon, M. B., Tudorache, I., Hilfiker-Kleiner, D., Mühlfeld, C., Schmitto, J. D., Müller M., Theilmeier, G. (2014). Expression of fibulin-6 in failing hearts and its role for cardiac fibroblast migration. Cardiovasc. Res. 103, 509-20

 

2013

  • Richardson, R., Slanchev, K., Kraus, C., Knyphausen, P., Eming, S. and Hammerschmidt, M. (2013). Adult zebrafish as a model for cutaneous wound-healing research. J. Invest. Dermatol. 133, 1655-1665

  • Liu, F., Pogoda, H.M., Pearson, C.A., Ohyama, K., Löhr, H., Hammerschmidt, M.* and Placzek, M.* (2013).  Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis. Development 140, 1111-1122  (*joint corresponding authors)

  • Geng, F.S., Abbas, L., Baxendale, S., Holdsworth, C.J., Swanson, A.G., Slnchev, K., Hammerschmidt, M., Topczeweski, J. and Whitfield, T. (2013). Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development 140, 4362-4374

  • van Dijk FS, Zillikens MC, Micha D, Riessland M, Marcelis CL, de Die-Smulders CE, Milbradt J, Franken AA, Harsevoort AJ, Lichtenbelt KD, Pruijs HE, Rubio-Gozalbo ME, Zwertbroek R, Moutaouakil Y, Egthuijsen J, Hammerschmidt M, Bijman R, Semeins CM, Bakker AD, Everts V, Klein-Nulend J, Campos-Obando N, Hofman A, te Meerman GJ, Verkerk AJ, Uitterlinden AG, Maugeri A, Sistermans EA, Waisfisz Q, Meijers-Heijboer H, Wirth B, Simon ME, Pals G. (2013). PLS3 mutations in X-linked osteoporosis with fractures. N. Engl. J. Med. 369, 1529-1536

  • Miyares, R.L., Stein, C., Renisch, B., Anderson, J.L., Hammerschmidt, M.* and Farber, S.A.* (2013). Long-chain Acyl-CoA synthetase regulates Smad activity and dorsoventral patterning in the zebrafish embryo. Dev. Cell 27, 635-647  (*joint corresponding authors)

 

2012

  • Naye, F., Voz, M. L., Detry, N., Hammerschmidt, M., Peers, B. and Manfroid, I. (2012). Essential roles of zebrafish bmp2a, fgf10 and fgf24 in the specification of the ventral pancreas. Mol Biol. Cell 23, 945-954

  • de Pater, E., Ciampricotti, M., Priller, F., Veerkamp, J., State, I., Smith, K., Lagendijk, A.K., Schilling, T., Herzog, W., Abdelilah-Seyfried, S., Hammerschmidt, M. and Bakkers, J. (2012). Bmp signalling exerts opposite effects on cardiac differentiation. Circ. Res. 110, 578-587

  • Asharani, P.V., Keupp, K., Semler, O., Wang, W., Li, Y., Thiele, H., Yigit, G., Pohl, E., Becker, J., Frommolt, P., Sonntag, C., Altmüller, J., Zimmermann, K., Greenspan, D.S., Akarsu, N.A., Netzer, C., Schönau, E., Wirth, R, Hammerschmidt, M., Nürnberg, P., Wollnik, B. and Carney, T.J. (2012). Attenuated. BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish. Am. J. Hum. Genet. 90, 661-674

  • Quiroz, Y., Lopez, M., Mavropoulos, A., Motte, P., Martial, J.A., Hammerschmidt, M. and Muller, M. (2012). The HMG-box transcription factor Sox4b is required for pituitary expression of gata2 and specification of the thyrotrope and gonadotrope cells in zebrafish. Mol. Endocrinol. 26, 1014-1027

  • Willenborg, S., Lucas, T., van Loo, G., Knipper, J.A., Krieg, T., Haase, I., Brachvogel, B., Hammerschmidt, M., Nagy, A., Ferrara, N., Pasparakis, M and Eming, S.A. (2012). CCR2 recurits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood 120, 613-625

  • Borgal, L., Habbig, S., Hatzold, J., Liebau, M.C., Sacarea, I., Hammerschmidt, M., Benzing, T. and Schermer, B. (2012). The ciliary protein Nephrocystin-4 translocates the canonical Wnt-regulator Jade-1 to the nucleus to negatively regulate beta-Catenin signaling. J. Biol. Chem. 287, 25370-25380

  • Talbot, J.C., Walker, M.B., Carney, T.C., Huycke, T.R., Yan, Y.-L., Bremiller, R.A., Gai, L., DeLaurier, A., Postlethwait, J.H., Hammerschmidt, M. and Kimmel, C.B. (2012). Fras1 shapes endodermal pouch 1 and stabilizes zebrafish pharyngeal skeletal development. Development 139, 2804-2813

  • Feitosa, N.M., Zhang, J., Carney, T.J., Metzger, M., Korzh, V., Bloch, W. and Hammerschmidt, M. (2012). Hemicentin2 and Fibulin1 are required for epidermal-dermal junction formation and fin mesenchymal cell migration during zebrafish development. Dev. Biol. 369, 235-248

  • von Ameln, S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, Nürnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, Nürnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A and Kubisch C. (2012). A mutation in PNPT1, encoding mitochondrial–RNA-import protein PNPase, causes hereditary hearing loss. Am. J. Human Genet. 91, 919-927

 

2011

  • Borck, G., Rehman, A. U., Lee, K., Pogoda, H.-M., Kakar, N., von Ameln, S., Grillet, N., Hildebrand, M. S., Ahmed, Z. M., Nürnberg, G., Ansar, M., Basit, S., Javed, Q., Morell, R. J., Nasreen, N., Shearer, A. E., Ahmad, A., Kahrizi, K., Shaikh, R. S., Ali, R. A., Khan, S. N., Goebel, I., Meyer, N. C., Kimberling, W. J., Webster, J. A., Stephan, D. A., Schiller, M., Bahlo, M., Najmabadi, H., Gillespie, P. G., Nürnberg, P., Wollnik, B., Riazuddin, S., Smith, R. J. H., Ahmad, W., Müller, U., Hammerschmidt, M., Friedman, T. B., Riazuddin, S., Leal, S. M., Ahmad, J. and Kubisch, C. (2011). Loss-of-function mutations of ILDRa cause autosomal recessive hearing impairment DFNB42. Am. J. Hum. Genet. 88, 127-137

  • Gibert, Y., Lattazani, V. J., Zhen, A. W., Vedder, L., Brunet, F., Babitt, L. L., Lin, H. Y., Hammerschmidt, M. and Fraenkel, P. G. (2011). BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin. PLoS One 6, e14553

  • Clark, K. J., Balciunas, D., Pogoda, H.-M., Ding, Y., Westco S. E., Bodell, V. M., Greenwood, T. M., Urban, M. D., Skuster, K. J., Petzold, A. M., Ni, J., Nielsen, A., Sivasubbu, S., Xu, X., Hammerschmidt, M. and Ekker, S. C. (2011). In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Nat. Methods 8, 506-515

  • Laue, K., Pogoda, H.-M., Daniel PB, van Haeringen A, Alanay Y, von Ameln S, Rachwalski M, Morgan T, Gray MJ, Breuning MH, Sawyer GM, Sutherland-Smith AJ, Nikkels PG, Kubisch C, Bloch W, Wollnik B, Hammerschmidt, M.*, Robertson, S.P.* (2011). Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid. Am. J. Hum. Genet. 89, 595-606 (* joint corresponding authors)

  • Feitosa, N., Richardson, R., Bloch, W. and Hammerschmidt, M. (2011). Basement membrane diseases in zebrafish. Methods Cell Biol. 105, 191-222 (including own, otherwise unpublished data)

  • Löhr, H. and Hammerschmidt, M. (2011). Zebrafish in the endocrine systems – recent advances and implications for human disease. Annu. Rev. Physiol. 73, 183-211 (including own, otherwise unpublished data)

 

2010

  • Jänicke, M., Renisch, B. and Hammerschmidt, M. (2010). Zebrafish grainyhead-like1 is a common marker of different non-keratinocyte epidermal cell lineages, which segregate from each other in a Foxi3-dependent manner. Int. J. Dev. Biol. 54, 837-850

  • Carney, T. J., Feitosa, N., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J., Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, R., Ingham, P.I. and Hammerschmidt, M. (2010). Genetic analysis of fin development in zebrafish identifies Furin and Hemicentin1 as potential novel Fraser Syndrome disease genes. PLoS Genet. 6, e1000907

  • Vuilleumier, R., Springhorn, A., Patterson, L., Koidl, S., Hammerschmidt, M., Affolter, M. and Pyrowolakis, G. (2010). Control of Dpp morphogen distribution by a secreted feedback inhibitor. Nat. Cell Biol 12, 611-617

  • Zhang, J.-L., Patterson L.J., Li-Yan Qiu, L.-Y., Graziussi, D., Sebald, W. and Hammerschmidt, M. (2010). Binding between Crossveinless-2 and Chordin Von Willebrand Factor type C domains promotes BMP signaling by blocking Chordin activity. PLoS One 5, e12846

  • Li, Y., Laue, K., Temtamy, S., Aglan, M., Kotan, L.D., Yigit, G., Husniye, C., Pawlik, B., Nürnberg, G., Wakeling, E.L., Quarrell, O.W., Baessmann, I., Lanktree, M.B., Yilmaz, M., Hegele, R.A., Amr, K., May, K.W., Nürnberg, P., Topaoglu, A.K., Hammerschmidt, M.* and Wollnik, B.* (2010). Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in Chondroitin synthase 1, a potential target of BMP signaling. Am. J. Hum. Genet. 87, 757-767   (* joint corresponding authors)

 

2009

  • Hammond K.L., Loynes H.E., Mowbray C., Runke G., Hammerschmidt M., Mullins M.C., Hildreth V., Chaudhry B. and Whitfield T.T. (2009). A late role for bmp2b in the morphogenesis of semicircular canal ducts in the zebrafish inner ear. PLoS ONE 4, e4368

  • Kleinridders, A., Pogoda, H.-M., Irlenbusch, S., Smyth, N., Koncz, C., Hammerschmidt, M. and Brüning J. C.  (2009). PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Mol. Cell. Biol. 29, 3173-3185

  • Dodd, M.E., Hatzold, J., Mathias, J.R., Walters, K.B., Bennin, D.A., Rhodes, J., Kanki, J.P., Look, A.T., Hammerschmidt M. and Huttenlocher A. (2009). The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development 136, 2591-2600

  • Slanchev, K., Carney, T. J., Stemmler, M. P., Koschorz, B., Amsterdam, A., Schwarz, H. and Hammerschmidt, M. (2009). The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. PLoS Genet. 5, e1000563

  • Eming, S. A., Hammerschmidt, M., Krieg T., Roers A. (2009). Interrelation of immunity and tissue repair or regeneration. Semin. Cell Dev. Biol. 20, 517-527

  • Pogoda, H.M. and Hammerschmidt, M. (2009). How to make a teleost adenohypophysis: molecular pathways of pituitary development in zebrafish. Mol. Cell. Endocrinol. 312, 2-13

 

2008

  • Smith K. A., Chocron, S., von der Hardt S., de Pater, E., Soufan, A., Bussmann, J., Schulte-Merker, S., Hammerschmidt, M. and Bakkers J. (2008). Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14, 287-297

  • Lengerke C., Schmitt S., Bowman T. V., Jang I. H., Maouche-Chretien L., McKinney-Freeman S., Davidson A. J., Hammerschmidt M., Rentzsch F., Green J. B., Zon L. I. and Daley G. Q. (2008). BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell 2, 72-82

  • Zhang, J.-L., Qui, L.-Y., Kotzsch, A., Weidauer, S., Patterson, L., Hammerschmidt, M., Sebald, W. and Mueller, T. D. (2008). Crystal structure analysis reveals how the Chordin family member Crossveinless 2 blocks BMP-2 receptor binding. Dev. Cell 14, 739-750

  • Laue, K., Dejaut, S., Crump, J. G., Plaster, N., Roehl, H. H., Kimmel, C. B., Schneider, R. and Hammerschmidt, M. (2008). The multidomain protein Brpf1 binds histones and is required for hox gene expression and segmental identity. Development 135, 1935-1946

  • Laue, K., Jänicke, M., Plaster, N., Sonntag, C. and Hammerschmidt, M. (2008). Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development. Development 135, 3775-3787

  • Laue, K., Jänicke, M., Plaster, N., Sonntag, C. and Hammerschmidt, M. (2008). Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development. Development 135, 3775-3787

 

2007

  • To, T.T., Hahner, S., Nica, G., Rohr, K. B., Hammerschmidt, M., Winkler, C. and Allolio, B. (2007). Pituitary-interrenal interaction in zebrafish interrenal organ development. Mol. Endocrinol. 21, 472-485

  • Dickmeis, T., Lahiri K., Nica, G., Vallone, D., Santoriello, C., Neumann, C. J., Hammerschmidt, M. and Foulkes, N. S. (2007). Glucocorticoids play a key role in circadian cell cycle rhythms. PLoS Biol. 5, e78

  • Choi, J., Dong, L. Ahn, J., Dao, D., Hammerschmidt, M. and Chen, J.-N. (2007). FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish. Dev. Biol. 304, 735-744

  • von der Hardt, S., Bakkers, J., Inbal, A., Carvalho, L., Solnica-Krezel, L., Heisenberg, C.-P. and Hammerschmidt, M. (2007). The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell adhesion. Curr. Biol. 17, 475-487

  • Bass, T., Ebert, M., Hammerschmidt, M. and Frank, M. (2007). Differential expression of four protocadherin alpha and gamma clusters in the developing and adult zebrafish: DrPcdh2g but not DrPcdh1g is expressed in neuronal precursor cells, ependymal cells and non-neural epithelia. Dev. Genes Evol. 217, 337-351

  • Chocron, S., Verhoeven, M.C., Rentzsch, F., Hammerschmidt, M. and Bakkers, J. (2007). Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Dev. Biol. 305, 577-588

  • Plaster, N., Sonntag, C. Schilling, T. F. and Hammerschmidt, M. (2007). REREa/Atrophin-2 interacts with Histone Deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development. Dev. Dyn. 236, 1891-1904

  • Shin, D., Shin, C. H., Tucker, J., Ober, E. A., Rentzsch, F., Poss, K. D., Hammerschmidt, M., Mullins, M. C. and Stainier, D. Y. (2007). Bmp and Fgf signaling are essential for liver specification in zebrafish. Development 134, 2041-2050

  • Jänicke, M., Carney, T. J. and Hammerschmidt, M. (2007). Foxi3 transcription factors and Notch signaling control the formation of skin ionocytes from epidermal precursors of the zebrafish embryo. Dev. Biol. 307, 258-271

  • Carney, T. J., von der Hardt, S., Sonntag, C., Amsterdam, A., Topczewski, J., Hopkins, N. and Hammerschmidt, M. (2007). Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development 134, 3461-3471

  • Pyati, U., Look A.T. and Hammerschmidt, M. (2007). Zebrafish as a powerful vertebrate model system for in vivo studies of cell death. Semin. Cancer Biol. 17, 154-165

  • Pogoda, H.-M. and Hammerschmidt, M. (2007). Molecular genetics of pituitary development in zebrafish. Semin. Cell Dev. Biol. 18, 543-558

 

2006

  • Plaster, N., Sonntag, C., Busse, C.E. and Hammerschmidt, M. (2006). p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase d1. Cell Death Diff. 13, 223-235

  • Rentzsch, F., Zhang, J., Kramer, C., Sebald, W. and Hammerschmidt, M. (2006). Crossveinless2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation. Development 133, 801-811

  • Nica, G., Herzog, W., Sonntag, C., Nowak, M., Schwarz, H., Zapata, A.G. and Hammerschmidt, M. (2006). Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis. Dev. Biol. 292, 189-204

  • Pogoda, H.-M., von der Hardt, S., Herzog, W., Kramer, C., Schwarz, H. and Hammerschmidt, M. (2006). The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis. Development 133, 1079-1089

  • Rentzsch, F., Anton, R., Saina, M., Hammerschmidt, M., Holstein, T. and Technau, U. (2006). Asymmetric expression of the BMP antagonists chordin and gremlin in the sea anemone Nematostella vectensis: Implications for the evolution of axial patterning. Dev. Biol. 296, 375-387

  • Ochi, H., Pearson, B.J., Chuang, P.T., Hammerschmidt, M. and Westerfield, M. (2006). Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened. Dev. Biol. 297, 127-140

  • Moeller, H., Jenny, A., Schaeffer, H.-J., Schwarz-Romond, T., Mlodzik, M., Hammerschmidt, M. and Birchmeier, W. (2006). Diversin regulates heart formation and gastrulation movements in development. Proc. Natl. Acad. Sci. USA 103, 15900-15905

  • Nowak, M. and Hammerschmidt, M. (2006). Ubc9 is required for mitosis and cell survival during zebrafish development. Mol. Biol. Cell 17, 5324-5336

  • Pickart, M.A., Klee, E.W., Nielsen, A.L., Sivasubbu, S., Mendenhall, E.M., Bill, B.R., Chen, E., Eckfeld, C.E., Knowlton, M., Robu, M.E., Larson, J.D., Deng, Y., Schimmenti, L.A., Ellis, L.B.M., Verfaillie, C.M., Hammerschmidt, M., Farber, S.A. and Ekker, S.C. (2006). Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome. PLoS ONE 1, e104 

 

2005

  • Leung, A.Y.H., Mandenhall, E.M., Kwan, T., Liang, R., Eckfeldt, C., Chen, E., Hammerschmidt, M., Grindley, S., Ekker, S.C. and Verfaillie, C.M. (2005). Characterization of expanded intermediate cell mass (ICM) in zebrafish chordin morphant embryos. Dev. Biol. 277, 235-254

  • Nowak, M., Köster, C. and Hammerschmidt, M. (2005). Perp is required for tissue-specific cell survival during zebrafish development. Cell Death Diff. 12, 52-64

  • Martinez-Morales, J.R., Del Bene, F., Nica, G., Hammerschmidt, M., Bovolenta, P. Wittbrodt, J. (2005). Differentiation of the vertebrate retina is coordinated by an FGF signaling center. Dev. Cell 8, 565-574

  • Bakkers, J., Camacho-Carvajal, M., Nowak, M., Kramer, C., Danger, B. and Hammerschmidt, M. (2005). Destabilization of ∆Np63a by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo. Cell Cycle 4, 790-800

  • Lopez, M., Nica, G., Motte, P., Martial, J.A., Hammerschmidt, M. and Muller, M. (2005). Expression of the somatolactin b gene during zebrafish embryonic development. Gene Exp. Patterns 6, 156-161

 

2004

  • Bakkers, J., Kramer, C., Pothof, J., Quaedvlieg, N.E.M., Spaink, H.P. and Hammerschmidt, M. (2004). Hyaluronan synthase 2 (Has2) is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development 131, 525-537

  • Herzog, W., Sonntag, C., Walderich, B., Odenthal, J., Maischein, H.-M., Tuebingen 2000 screen consortium and Hammerschmidt, M. (2004). Genetic analysis of adenohypophysis formation in zebrafish. Mol. Endocrinol. 18, 1185-1195

  • Nica, G., Herzog, W., Sonntag, C. and Hammerschmidt, M. (2004). Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism. Mol. Endocrinol. 18, 1196-1209

  • Herzog, W., Sonntag. C., Roehl, H. H., Varga, Z. and Hammerschmidt, M. (2004). Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis. Development 131, 3681-3692

  • Brembeck, F.H., Schwarz-Ramond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M. and Birchmeier, W. (2004). Essential role of BCL9-2 in the switch of b-catenins’s adhesive and transcriptional functions. Genes Dev. 18, 2225-2230

  • Rentzsch, F., Bakkers, J., Kramer, C. and Hammerschmidt, M. (2004). Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition. Dev. Dyn. 231, 750-757

 

2003

  • Herzog, W., Zeng, X., Sonntag, C., Ting, J.-W., Chang, C.-Y., and Hammerschmidt, M. (2003). Adenohypohysis formation in the zebrafish and its dependence on Sonic Hedgehog. Dev. Biol. 254, 36-49

  • Hammerschmidt, M., Kramer, C., Nowak, M., Herzog, W. and Wittbrodt, J. (2003). Loss of maternal Smad5 in zebrafish embryos affects patterning and morphogenesis of the optic primordia. Dev. Dyn. 227, 128-133

  • Liu, N.-A., Huang, H., Yang, Z., Herzog, W., Hammerschmidt, M., Lin, S. and Melmed, S. (2003). Pituitary corticotroph ontogeny and regulation in transgenic zebrafish. Mol. Endocrinol., 17, 959-966

  • Masai, I., Lele, Z., Yamaguchi, M., Komori, A., Nakata, A., Nishiwaki, Y., Wada, H., Tanaka, H., Nojima, Y., Hammerschmidt, M., Wilson, S.W. and Okamato, H. (2003). N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites. Development 130, 2479-2494

  • Rentzsch, F., Kramer, C. and Hammerschmidt, M. (2003). Specific and conserved roles of TAp73 during zebrafish development. Gene 323C, 19-30

  • Bally-Cuif, L. and Hammerschmidt, M. (2003). Induction and patterning of neural development, and its connection to cell cycle control. Curr. Opin. Neurobiol. 13, 16-25

 

2002

  • Bai, R.Y., Koester, C., Ouyang, T., Hahn, S.A., Hammerschmidt, M., Peschel, C. and Duyster, J. (2002). SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling. Nat. Cell. Biol. 4, 81-90

  • Bakkers, J., Hild, M., Kramer, C., Furutani-Seiki, M. and Hammerschmidt, M. (2002). Zebrafish ∆Np63 is a direct target of Bmp signaling and acts as a transcriptional repressor to block neural specification in the ventral ectoderm. Dev. Cell 2, 617-627

  • Lele, Z., Folkert, A., Concha, M., Rauch, G.J., Geisler, R., Rosa, F., Wilson, S.W., Hammerschmidt, M*. and Bally-Cuif, L. (2002). parachute / n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube. Development 129, 3281-3294 (*corresponding author)

  • Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kühl, M., Schaeffer, H.-J., Huesken, J., Behrens, J., Hammerschmidt, M. and Birchmeier, W. (2002). The ankyrin repeat protein Diversin recruits Casein kinase Ie to the b-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev. 16, 2072-2084

  • Schorpp, M., Leicht, M., Nold, E., Hammerschmidt, M., Haas-Assenbaum, A., Wiest, W. and Boehm, T. (2002). A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment. Mech. Dev. 118, 179-185

  • Kramer, C., Mayr, T., Nowak, M., Schumacher, J., Runke, G., Bauer, H., Wagner, D.S., Schmid, B., Imai, Y., Talbot, W.S., Mullins, M.C. and Hammerschmidt, M. (2002). Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling. Dev. Biol. 250, 263-279

 

2001

  • Bauer, H., Lele, Z., Rauch, G.-J., Geisler, R. und Hammerschmidt, M. (2001). The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signaling during dorsoventral patterning of the zebrafish embryo. Development 128, 849-858

  • Topczewski, J. Sepich, D.S., Myers, D.C., Walker, C. Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J. and Solnica-Krezel, L. (2001). The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension. Dev. Cell 1, 251-264

  • Lele, Z., Bakkers, J. and Hammerschmidt, M. (2001). Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick and pipetail mutations. Genesis 30, 190-194

  • Mowbray, C., Hammerschmidt, M. and Whitfield, T.T. (2001) Expression of BMP signalling pathway members in the developing zebrafish inner ear and lateral line. Mech. Dev. 108, 179-184

  • Lele, Z., Nowak, M. and Hammerschmidt, M. (2001). Zebrafish admp is required to restrict the size of the organizer and to promote posterior and ventral development. Dev. Dyn. 222, 681-687